Intravenous immunoglobulin for vaccine induced thrombotic thrombocytopenia

SARS-CoV-2 vaccines

The use of high-dose intravenous immunoglobulin (IVIG), in addition to anticoagulants, is recommended for the treatment of vaccine-induced immune thrombotic thrombocytopenia (VITT), a rare side effect of adenoviral vector vaccines against Covid-19, similar to autoimmune heparin-induced thrombocytopenia. IVIG had been shown effective in inhibiting platelet activation by patients’ antibodies. Three patients (age between 63 and 72 years; one female) in whom VITT was [...]

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